徐波:国家级人才

编辑:刘念 发布时间:2020-05-08 11:54

徐波 教授

重庆大学附属肿瘤医院院长/重庆大学弘深杰出学者

学习经历

1998/10-2002/08 美国 St Jude 儿童研究医院 博士后 (合作导师: Michael B Kastan)

1995/09–1998/05 协和医科大学 医学博士 (导师:殷蔚伯)

1992/09–1995/07 天津医科大学 医学硕士 (导师: 杨天恩、浦佩玉)

1985/09–1990/07 白求恩医科大学 医学学士


工作经历

2020/04-至今 重庆大学附属肿瘤医院 院长;重庆大学弘深杰出学者;乳腺癌智能诊疗重庆市重点实验室 主任

2016/11-2020/04 天津医科大学肿瘤医院 副院长;乳腺癌教育部重点实验室常务副主任;天津乳腺癌诊疗中心 执行主任

2012/08-2016/11 美国南方研究院肿瘤学系 系主任/杰出研究员(Distinguished Fellow and Chairman);美国阿拉巴马大学伯明翰分校病理系、细胞生物学系教授

2009/08-2012/08 美国康奈尔大学柠檬导航官网地址入口附属卫理教会医院 资深研究员/终身教授/主任

2006/06-2009/08 美国南方研究院/阿拉巴马大学柠檬导航官网地址入口 高级研究员/副教授

2002/08-2006/05 美国路易斯安娜州立大学 助理教授(tenure track)


学术兼职

中国抗癌协会肿瘤人工智能专业委员会 主任委员

中国医药卫生事业发展基金会肿瘤防治专家委员会 副主任委员

中国医疗保健国际交流促进会鼻咽癌防治分会 副主任委员

中国医药卫生文化协会医疗健康信用分会 副会长

Radiotherapy and Oncology 编委


代表性文章

n Xiao M, Zhang S, Liu Z, Mo Y, Wang H, Zhao X, Yang X, Boohaker RJ, Chen Y, Han Y, Liu H, Xu B. Dual-functional significance of ATM-mediated phosphorylation of spindle assembly checkpoint component Bub3 in mitosis and the DNA damage response. JBC2022 Mar;298(3):101632.

n Liu Z, Xiao M, Mo Y, Wang H, Han Y, Zhao X, Yang X, Liu Z, Xu B. Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy. Int J Biol Sci. 2022 May 9;18(8):3447-3457.

n Meng F, Su Y, Xu B. Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer. Mol Oncol. 2020 Nov;14(11):2701-2712.

n Wang S, Kang B, Ma J, Zeng X, Xiao M, Guo J, Cai M, Yang J, Li Y, Meng X, Xu B. A deep learning algorithm using CT images to screen for Corona virus disease (COVID-19). Eur Radiol. 2021 Aug;31(8):6096-6104. ESI Highly cited (1%), Hot paper (0.1%)

n Ma Z, Wang H, Meng F, Han Y, Chen Y, Xiao M, Jiang H, Yu Z, Xu B. Role of BCLAF-1 in PD-L1 stabilization in response to ionizing irradiation. Cancer Sci. 2021 Oct;112(10):4064-4074.

n Xiao M, Fried JS, Ma J, Su Y, Boohaker RJ, Zeng Q, Mo Y, Meng F, Xiang R, Xu B. A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response. Signal Transduct Target Ther. 2021 Jan 15;6(1):17.

n Boohaker RJ, Sambandam V, Segura I, Miller J, Suto M, Xu B. Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction. Cancer Lett. 2018 Oct 10;434:11-21.

n Gao Y, Wu N, Wang S, Yang X, Wang X, Xu B. Concurrent mutations associated with trastuzumab-resistance revealed by single cell sequencing. Breast Cancer Res Treat. 2021 Jun;187(3):613-624.

n Xiaojing Guo, Chunying Yang , Xiaolong Qian , Ting Lei , Yaqing Li , Haifa Shen , Li Fu and Bo Xu. Estrogen Receptor Alpha regulates ATM expression through miRNAs in breast cancer, Clinical Cancer Research, 2013 Sep 15;19(18):4994-5002.

n Siddoway BA; Altimimi HF; Hou H; Petralia S; Xu B; Stellwagen D; Xia H. An Essential Role for Inhibitor-2-Regualred Protein Phosphatase 1 in Synaptic Downscaling. J Neuroscience 33[27], 11206-11211. 2013.

n Jinping Liu, Shukun Luo, Hongchang Zhao, Ji Liao, Jing Li, Chunying Yang, Bo Xu, David F. Stern, Xingzhi Xu,and Keqiong Ye, Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain. Nucleic Acids Research, 2012 Jan 10. 409),3898-3912

n Mianen Sun, Xiaojing Guo, Chunying Yang, Kathryn Brinkman, David Engler, Binhua Zhou, Li Fu, Bo Xu. Activation of the ATM-Snail pathway promotes breast cancer metastasis, Journal of Molecular Cell Biology, 2012 Oct;4(5):304-15

n Chunying Yang, Mike Lee, Jessie Tang, Xiaoli Cui, Paula Allen, Françoise Bontemps, William B. Parker, and Bo Xu.  Deoxycytidine kinase regulates the G2M checkpoint through interaction with Cyclin-Dependent Kinase 1 in response to DNA damage. Nucleic Acids Research, 20124019):9621-9632

n Chunying Yang, Xi Tang, Xiaojing Guo, Yohei Niikura, Katsumi Kitagawa, Kemi Cui, Stephen T.C. Wong, Li Fu, and Bo Xu. Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required For Mitotic ATM Activation and the Spindle Checkpoint. Molecular Cell. 44, 597-608 November 18, 2011. (appeared as issue highlights, article previewed, top-read, and Faculty of 1000 Prime recommended)

n Xi Tang, Zhou-guang Hui, Xiao-li Cui, Renu Garg, Michael B. Kastan, and Bo Xu*. A novel ATM-dependent pathway regulates Protein Phosphatase 1 and histone H3 phosphorylation in response to DNA damage.   Molecular and Cellular Biology (MCB), April 4, 2008, 2559-2566, Faculty of 1000 Prime recommended

n Mickael Cariveau, Jessie Tang, Xiaoli Cui, and Bo Xu. Conserved NBS1 C-terminal small peptides can inhibit the ATM-mediated DNA damage response and enhance radiation sensitivity. Molecular Pharmacology, AUG 2007, 72 (2): 320-326.  

n Stephen L. Gasior, Timothy Wakeman, Bo Xu, Prescott L. Deininger. The human LINE-1 Retrotransposon Creates DNA DSBs. J Mol Biol.2006 Apr 14; 357(5):1383-93.

n Garg, R., Geng, C.-D., Miller, J. L., Callens, S., Tang, X., Appel, B., Xu, B. Molecular Cloning and Characterization of the Catalytic Domain of Zebrafish Homologue of the Ataxia-Telangiectasia Mutated Gene. Molecular Cancer Research 2: 348-353, 2004. Also featured the cover page of the issue.

n Garg, R., Callens, S., Lim, D.-S., Canman, C. E., Kastan, M. B., Xu, B. Chromatin Association of Rad17 Is Required for an Ataxia Telangiectasia and Rad-Related Kinase-Mediated S-Phase Checkpoint in Response to Low-Dose Ultraviolet Radiation. Molecular Cancer Research 2: 362-369, 2004.

n Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH, Kastan MB. Atm phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404:613-617; 2000. Faculty of 1000 Prime recommended

n Xu B, Kim ST and Kastan MB. Involvement of Brca1 in S-phase and G2-phase checkpoint after ionizing irradiation   Molecular and Cellular Biology 21: 3445-3450; 2001. Faculty of 1000 Prime recommended

n Kim ST, Xu B (co-first author) and Kastan MB.  Involvement of the Cohesin Protein, Smc1, in ATM– Dependent and –Independent Responses to DNA Damage.  Genes & Development 16: 560-570, 2002. Faculty of 1000 Prime recommended

n Xu B, Kim St, Lim DS, Kastan MB.  Two Molecularly Distinct G2/M checkpoints Are Induced by Ionizing Irradiation Molecular and Cellular Biology (MCB) 22 (4): 1049-1059; 2002.

n Taniguchi T, Garcia-Higuera I, Xu B, Anderson P, Gregory R, Lane W, Kim S, Kastan MB, D’Andrea A. Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways. Cell 09: 459-472, 2002. Faculty of 1000 Prime recommended

n Xu B, O’Donnell AH, Kim ST, Kastan MB. Phosphorylation of Serine 1387 in Brca1 is specifically required for the Atm-Mediated S-phase Checkpoint after Ionizing Irradiation.  Cancer Research. Aug 15; 62(16):4588-91, 2002.


研究方向及科研成就

徐波教授主要研究方向为基因组稳定性、DNA损伤修复机制及人工智能在肿瘤诊疗中的应用,在权威杂志(《Nature》、《Cell》、《Molecular Cell》等)发表100余篇SCI文章,被引用超过11000次6篇文章入选F1000推荐系列,12篇文章入选ESI高被引(top 1%),1篇热点文章(top 1H指数44 旅美期间(1998-2018)先后担任美国康奈尔大学柠檬导航官网地址入口卫理公会医院教授,美国南方研究院肿瘤学系主任、美国阿拉巴马大学伯明翰分校病理学教授,美国国立癌症研究所 NCI)化学生物学中心 (CBC)执行委员会委员,南方研究院CBC中心共同主任,美国放射学院放射肿瘤学住院医师执业医师考核委员美国国立卫生研究院科研基金评审委员,美国国防部乳腺癌研究项目课题评审委员等。作为课题负责人主持联邦课题8项,研究经费超过800万美元,包括2项R01,1项P20及其它NIH课题

徐波教授团队系统研究DNA 损伤后细胞周期检查点的调控机制,阐明ATM、BRCA1、NBS1SPOPPDL1等蛋白在DNA损伤应答机制及有丝分裂中的功能建立了一系列方法研究 DNA 损伤修复过程中蛋白质的相互作用及细胞周期检查点的信号转导通路揭示了过度激活的DNA损伤修复与乳腺癌转移之间的关系先后克隆出斑马鱼ATM及NBS1基因,为建立斑马鱼的肿瘤模型提供了重要基础;团队提出应用核苷类似物新药合治疗方案于2017年获得国际专利1项2018年研发出国际首例多肽免疫检测点抑制剂。全职回国后先后完成极年轻乳腺癌基因组图谱、小细胞肺癌、贲门癌多组学研究,2022年完成有丝分裂期ATM激酶底物图谱并鉴定其与DNA损伤修复的交叉机制。徐波教授2019年在国际上首次提出智能肿瘤学概念,2019年当选为中国抗癌协会肿瘤人工智能专委会首任主任委员,建立了基于人工智能的乳腺癌快速病理分子诊断系统,该项工作在中央电视台《经济半小时》中得到专题报道,是建国70周年超级计算机应用的重要案例2020年2月成功开发国际首例可用于辅助诊断新冠肺炎的AI+CT模型,相关文章2021入选ESI热点论文(1‰)。2022年徐波教授主编的《智能肿瘤学》荣获国家出版基金支持。